Table 5.
Locations of experimentally determined regions/residues
| Region/residue | Location | References |
|---|---|---|
| N‐terminal | Cytoplasmic | Ezaki et al. (2003) and Ratajczak et al. (2014) |
| 1–33 | Cytoplasmic | |
| 2–18 | Lumenal | Mao, Foster, et al. (2003) and Mao, Xia, et al. (2003) |
| N71 | Lumenal | |
| N85 | Lumenal | Storch et al. (2007) |
| *97–121 | MSD | [SPEP + Ensemble 1.0, MEMSAT3, + Swissprot, MEMSAT3 + CLN3, TMHMM 2.0, PHOBIUS Constrained, PROFPHD, HMMTOP] |
| 199 | Lumenal | Mao, Foster, et al. (2003) |
| 210–231 | MSD | [SPEP + Ensemble 1.0, MEMSAT3, + Swissprot, MEMSAT3 + CLN3, TMHMM 2.0, PHOBIUS Constrained, PROFPHD, HMMTOP] |
| 250–264 | Cytoplasmic | Mao, Foster, et al. (2003) and Mao, Xia, et al. (2003) |
| 242–258 | Cytoplasmic | Kyttälä et al. (2004) |
| *276–303 | MSD | [SPEP + Ensemble 1.0, MEMSAT3, + Swissprot, MEMSAT3 + CLN3, TMHMM 2.0, PHOBIUS Constrained, PROFPHD, HMMTOP] |
| N310 | Lumenal | Mao, Foster, et al. (2003) and Storch et al. (2007) |
| 321 | Lumenal | Mao, Foster, et al. (2003) |
| S401 | Cytoplasmic | Kyttälä et al., (2004) and Ratajczak et al. (2014) |
| 406–433 | Cytopasmic | Nugent et al. (2008) |
| Cys435 | Cytoplasmic | Storch et al. (2007) |
| C‐terminal | Cytoplasmic | Mao, Xia, et al. (2003) and Ratajczak et al. (2014) |
*
Computer Modeling was included for MSDs for which all prediction models support the same conclusion.