Figure 5.

The exosome-mediated transfer of cancer-derived products from distal tumor to salivary gland. Cancer-derived exosomes enter the circulation and reach salivary glands. Exosome uptake at salivary gland acinar cells occurs via endocytosis or membrane fusion. Two salivary exosomes are released into saliva. Cancer-derived exosomes are released through exocytosis, while acinus-derived exosomes are released through fusion of multivesicular bodies with the plasma membrane. Both types of salivary exosomes carry cargos that include cancer-derived products. Permission from Elsevier.