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. 2019 Dec 3;6(6):ENEURO.0311-19.2019. doi: 10.1523/ENEURO.0311-19.2019

Figure 2.

Figure 2.

Behavioral data analysis. A, Analysis of passive avoidance data. Two-way RM ANOVA detected a significant difference in the latency of all groups between the training and testing days. During the testing day, a statistical significance was detected between sham and acquisition groups. #Habituation data were collected from only eight animals per group; * and ** indicate statistical significance (p < 0.05 and p < 0.001, respectively). B, Cox proportional hazard regression analysis for PAT data on training day. No statistical group separation was detected. C, Cox proportional hazard regression analysis for PAT data on testing day. A significant group difference was detected (log-rank Χ 2 = 7.0919, df = 2, p = 0.0288). D, PCA with proteomics data show the distribution of each samples across the groups. E, Hierarchical clustering analysis with proteomics data show the distribution of each sample across the groups. Red, green, and blue boxes represent sham, retrieval, and acquisition samples. Protein IDs in the first hierarchical clustering group, from left to right, are KDELC2, EXOC6, UFL1, CDH8, ARHGAP27, BLNK, MPPED2, GFM1, FNTB, WASH, PDE4DIP, TUBA4A, ACVR1B, PRKAR1B, RBMX2, ZFYVE27, CAPN5, PSME1, KCNA6, LLGL1, JAM3, CD151, S1PR5, and GPSM1. The hierarchical clustering group 2 includes, from left to right, LHX1, GUCY1A2, STX8, CSAD, USP19, FTSJD2, DNAH7, LOC362863, RAB9A, GSTZ1, PDIA4, RPH3AL, LRFN1, STK39, CCDC116, LOC100911646, GLS, PYROXD2, LOC100911456, AOC3, MYO1C, and ILK. For the cluster group 3, protein IDs are INHBA, EIF3J, SLC20A1, ZRANB2, CCDC127, FAM195B, GLDN, FHIT, PNPO, PGP, TUBA1C, ACBD6, MCCC1, NOP58, ITGAD, RPL27, ABCF1, WDR81, and COTL1. The cluster group 4 contains proteins named as, from left to right, CACNA1D, GHITM2, SCFD1, PTP4A2, ZW10, GCLM, APMAP, CRP, SRP54, PTPRN2, SRP542, ADCY6, CAR3, COL3A1, IP6K1, GOLPH31, SLC27A1, RILPL1, PFKFB1, PSMA2, and ICOS. Proteins from the cluster group 5 are GALE, EQTN, CLUL1, GABRB2, MRPS25, MRAS, SCYL1, OXCT1, FAM194A, FAM213B, LAMP5, SNX1, CNIH2, GHITM, SLC29A3, and AK6. Proteins in the cluster group 6 are MARK2, HOMER3, GPHN, RAB3GAP2, RBP1, PALMD, MCCC2, ARHGEF11, and LRRC57. For a clear figure, see Extended Data Figure 2-1.