Table 3. FPRP values for associations between the risk of cancer and the frequency of genotypes.
Comparison | Subgroup | n | PZ | OR (95% CI) | Statistical power | ||||
---|---|---|---|---|---|---|---|---|---|
0.25 | 0.1 | 0.01 | 0.001 | ||||||
(-196 to -174del) | |||||||||
B vs. A | Overall | 18 | 0.005* | 1.468 (1.129–1.91) | 0.564 | 0.022† | 0.064† | 0.427 | 0.883 |
BB vs. AA | Overall | 18 | 0.005* | 1.716 (1.178–2.5) | 0.237 | 0.054† | 0.146† | 0.652 | 0.950 |
BA vs. AA | Overall | 18 | 0.008* | 1.408 (1.092–1.816) | 0.683 | 0.035† | 0.099† | 0.547 | 0.924 |
BB+BA vs. AA | Overall | 18 | 0.007* | 1.449 (1.107–1.897) | 0.597 | 0.034† | 0.096† | 0.539 | 0.922 |
BB vs. BA+ AA | Overall | 18 | 0.013* | 1.517 (1.092–2.107) | 0.468 | 0.073† | 0.192† | 0.723 | 0.963 |
B vs. A | Asian | 11 | 0.043* | 1.169 (1.005–1.361) | 0.999 | 0.117† | 0.285 | 0.814 | 0.978 |
BB+BA vs. AA | Asian | 11 | 0.033* | 1.203 (1.015–1.427) | 0.994 | 0.106† | 0.262 | 0.796 | 0.975 |
B vs. A | Caucasian | 3 | 0.028* | 3.291 (1.139–9.51) | 0.073 | 0.532 | 0.773 | 0.974 | 0.997 |
BB vs. AA | Caucasian | 3 | 0.008* | 9.878 (1.83–53.322) | 0.014 | 0.621 | 0.831 | 0.982 | 0.998 |
BA vs. AA | Caucasian | 3 | 0.044* | 3.156 (1.034–9.634) | 0.096 | 0.577 | 0.804 | 0.978 | 0.998 |
BB+BA vs. AA | Caucasian | 3 | 0.034* | 3.555 (1.098–11.51) | 0.075 | 0.579 | 0.805 | 0.978 | 0.998 |
BB vs. BA+ AA | Caucasian | 3 | 0.006* | 7.294 (1.752–30.369) | 0.015 | 0.561 | 0.793 | 0.977 | 0.998 |
B vs. A | PB | 14 | 0.001* | 1.576 (1.193–2.08) | 0.364 | 0.011† | 0.031† | 0.263 | 0.783 |
BB vs. AA | PB | 14 | 0.001* | 2.274 (1.43–3.616) | 0.040 | 0.039† | 0.108† | 0.571 | 0.931 |
BA vs. AA | PB | 14 | 0.005* | 1.543 (1.143–2.081) | 0.427 | 0.031† | 0.086† | 0.510 | 0.913 |
BB+BA vs. AA | PB | 14 | 0.002* | 1.624 (1.186–2.223) | 0.310 | 0.023† | 0.067† | 0.441 | 0.888 |
BB vs. BA+ AA | PB | 14 | 0.001* | 2.011 (1.317–3.07) | 0.087 | 0.040† | 0.111† | 0.578 | 0.933 |
B vs. A | Y | 15 | 0.008* | 1.447 (1.103–1.897) | 0.603 | 0.036† | 0.101† | 0.551 | 0.925 |
BB vs. AA | Y | 15 | 0.004* | 1.915 (1.227–2.991) | 0.141 | 0.083† | 0.214 | 0.750 | 0.968 |
BA vs. AA | Y | 15 | 0.02* | 1.422 (1.057–1.915) | 0.637 | 0.088† | 0.224 | 0.760 | 0.970 |
BB+BA vs. AA | Y | 15 | 0.013* | 1.494 (1.088–2.052) | 0.510 | 0.072† | 0.189 | 0.719 | 0.963 |
BB vs. BA+ AA | Y | 15 | 0.009* | 1.673 (1.137–2.461) | 0.290 | 0.085† | 0.218 | 0.754 | 0.969 |
BA vs. AA | N | 3 | 0.039* | 1.335 (1.015–1.757) | 0.797 | 0.129† | 0.307 | 0.830 | 0.980 |
rs3804099 | |||||||||
BA vs. AA | Overall | 9 | 0.008* | 0.827 (0.717–0.952) | 0.999 | 0.024† | 0.069† | 0.448 | 0.891 |
BB+BA vs. AA | Overall | 9 | 0.016* | 0.85 (0.744–0.97) | 1.000 | 0.045† | 0.125† | 0.611 | 0.941 |
BB vs. AA | Asian | 5 | 0.005* | 0.65 (0.482–0.877) | 0.434 | 0.032† | 0.091† | 0.524 | 0.917 |
BA vs. AA | Asian | 5 | 0.001* | 0.69 (0.55–0.867) | 0.287 | 0.064† | 0.170† | 0.692 | 0.958 |
B vs. A | Gastric cancer | 2 | 0.002* | 0.728 (0.594–0.893) | 0.801 | 0.009† | 0.025† | 0.223 | 0.743 |
BB vs. AA | Gastric cancer | 2 | 0.026* | 0.605 (0.389–0.942) | 0.334 | 0.190† | 0.413 | 0.886 | 0.987 |
BA vs. AA | Gastric cancer | 2 | 0.018* | 0.706 (0.529–0.942) | 0.652 | 0.076† | 0.199† | 0.732 | 0.965 |
BB+BA vs. AA | Gastric cancer | 2 | 0.004* | 0.681 (0.524–0.886) | 0.563 | 0.022† | 0.063† | 0.426 | 0.882 |
BB vs. BA+ AA | Colon cancer | 2 | 0.034* | 0.841 (0.716-0.987) | 0.998 | 0.093† | 0.235 | 0.771 | 0.971 |
BA vs. AA | HB | 4 | 0.005* | 0.713 (0.564–0.902) | 0.712 | 0.020† | 0.057† | 0.400 | 0.871 |
BB+BA vs. AA | HB | 4 | 0.005* | 0.734 (0.591–0.912) | 0.807 | 0.019† | 0.055† | 0.391 | 0.867 |
B vs. A | Y | 5 | 0.036* | 0.895 (0.807–0.993) | 1.000 | 0.098† | 0.247 | 0.783 | 0.973 |
BB+BA vs. AA | Y | 5 | 0.028* | 0.844 (0.725–0.982) | 0.999 | 0.078† | 0.202 | 0.736 | 0.966 |
BA vs. AA | N | 4 | 0.042* | 0.73 (0.54–0.988) | 0.722 | 0.147† | 0.341 | 0.851 | 0.983 |
rs3804100 | |||||||||
BB vs. BA+ AA | HB | 4 | 0.033* | 1.449 (1.031–2.036) | 0.579 | 0.144† | 0.336 | 0.848 | 0.983 |
rs4696480 | |||||||||
B vs. A | Overall | 4 | 0.03* | 1.216 (1.019–1.452) | 0.990 | 0.085† | 0.218 | 0.754 | 0.969 |
BB vs. AA | Overall | 4 | 0.032* | 1.463 (1.034–2.069) | 0.556 | 0.145† | 0.337 | 0.848 | 0.983 |
B vs. A | Caucasian | 2 | 0.007* | 1.393 (1.094–1.775) | 0.725 | 0.029† | 0.084† | 0.501 | 0.910 |
BB vs. AA | Caucasian | 2 | 0.009* | 1.903 (1.171–3.091) | 0.168 | 0.143† | 0.333 | 0.846 | 0.982 |
BA vs. AA | Caucasian | 2 | 0.001* | 1.984 (1.307–3.012) | 0.095 | 0.040† | 0.110† | 0.576 | 0.932 |
BB+BA vs. AA | Caucasian | 2 | 0.001* | 1.95 (1.317–2.887) | 0.095 | 0.026† | 0.075† | 0.470 | 0.899 |
Statistical power was calculated using the number of observations in the subgroup and the OR and P values in this table. Abbreviations: CI, confidence interval; H-B, hospital based; HWE (Y), polymorphisms conformed to HWE in the control group.
*P-value less than 0.05 was considered as statistically significant.
†The significant result with the FPRP values less than 0.2 was considered a worthy finding.