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. 2019 Dec 6;39(12):BSR20191698. doi: 10.1042/BSR20191698

Table 3. FPRP values for associations between the risk of cancer and the frequency of genotypes.

Comparison Subgroup n PZ OR (95% CI) Statistical power
0.25 0.1 0.01 0.001
(-196 to -174del)
B vs. A Overall 18 0.005* 1.468 (1.129–1.91) 0.564 0.022 0.064 0.427 0.883
BB vs. AA Overall 18 0.005* 1.716 (1.178–2.5) 0.237 0.054 0.146 0.652 0.950
BA vs. AA Overall 18 0.008* 1.408 (1.092–1.816) 0.683 0.035 0.099 0.547 0.924
BB+BA vs. AA Overall 18 0.007* 1.449 (1.107–1.897) 0.597 0.034 0.096 0.539 0.922
BB vs. BA+ AA Overall 18 0.013* 1.517 (1.092–2.107) 0.468 0.073 0.192 0.723 0.963
B vs. A Asian 11 0.043* 1.169 (1.005–1.361) 0.999 0.117 0.285 0.814 0.978
BB+BA vs. AA Asian 11 0.033* 1.203 (1.015–1.427) 0.994 0.106 0.262 0.796 0.975
B vs. A Caucasian 3 0.028* 3.291 (1.139–9.51) 0.073 0.532 0.773 0.974 0.997
BB vs. AA Caucasian 3 0.008* 9.878 (1.83–53.322) 0.014 0.621 0.831 0.982 0.998
BA vs. AA Caucasian 3 0.044* 3.156 (1.034–9.634) 0.096 0.577 0.804 0.978 0.998
BB+BA vs. AA Caucasian 3 0.034* 3.555 (1.098–11.51) 0.075 0.579 0.805 0.978 0.998
BB vs. BA+ AA Caucasian 3 0.006* 7.294 (1.752–30.369) 0.015 0.561 0.793 0.977 0.998
B vs. A PB 14 0.001* 1.576 (1.193–2.08) 0.364 0.011 0.031 0.263 0.783
BB vs. AA PB 14 0.001* 2.274 (1.43–3.616) 0.040 0.039 0.108 0.571 0.931
BA vs. AA PB 14 0.005* 1.543 (1.143–2.081) 0.427 0.031 0.086 0.510 0.913
BB+BA vs. AA PB 14 0.002* 1.624 (1.186–2.223) 0.310 0.023 0.067 0.441 0.888
BB vs. BA+ AA PB 14 0.001* 2.011 (1.317–3.07) 0.087 0.040 0.111 0.578 0.933
B vs. A Y 15 0.008* 1.447 (1.103–1.897) 0.603 0.036 0.101 0.551 0.925
BB vs. AA Y 15 0.004* 1.915 (1.227–2.991) 0.141 0.083 0.214 0.750 0.968
BA vs. AA Y 15 0.02* 1.422 (1.057–1.915) 0.637 0.088 0.224 0.760 0.970
BB+BA vs. AA Y 15 0.013* 1.494 (1.088–2.052) 0.510 0.072 0.189 0.719 0.963
BB vs. BA+ AA Y 15 0.009* 1.673 (1.137–2.461) 0.290 0.085 0.218 0.754 0.969
BA vs. AA N 3 0.039* 1.335 (1.015–1.757) 0.797 0.129 0.307 0.830 0.980
rs3804099
BA vs. AA Overall 9 0.008* 0.827 (0.717–0.952) 0.999 0.024 0.069 0.448 0.891
BB+BA vs. AA Overall 9 0.016* 0.85 (0.744–0.97) 1.000 0.045 0.125 0.611 0.941
BB vs. AA Asian 5 0.005* 0.65 (0.482–0.877) 0.434 0.032 0.091 0.524 0.917
BA vs. AA Asian 5 0.001* 0.69 (0.55–0.867) 0.287 0.064 0.170 0.692 0.958
B vs. A Gastric cancer 2 0.002* 0.728 (0.594–0.893) 0.801 0.009 0.025 0.223 0.743
BB vs. AA Gastric cancer 2 0.026* 0.605 (0.389–0.942) 0.334 0.190 0.413 0.886 0.987
BA vs. AA Gastric cancer 2 0.018* 0.706 (0.529–0.942) 0.652 0.076 0.199 0.732 0.965
BB+BA vs. AA Gastric cancer 2 0.004* 0.681 (0.524–0.886) 0.563 0.022 0.063 0.426 0.882
BB vs. BA+ AA Colon cancer 2 0.034* 0.841 (0.716-0.987) 0.998 0.093 0.235 0.771 0.971
BA vs. AA HB 4 0.005* 0.713 (0.564–0.902) 0.712 0.020 0.057 0.400 0.871
BB+BA vs. AA HB 4 0.005* 0.734 (0.591–0.912) 0.807 0.019 0.055 0.391 0.867
B vs. A Y 5 0.036* 0.895 (0.807–0.993) 1.000 0.098 0.247 0.783 0.973
BB+BA vs. AA Y 5 0.028* 0.844 (0.725–0.982) 0.999 0.078 0.202 0.736 0.966
BA vs. AA N 4 0.042* 0.73 (0.54–0.988) 0.722 0.147 0.341 0.851 0.983
rs3804100
BB vs. BA+ AA HB 4 0.033* 1.449 (1.031–2.036) 0.579 0.144 0.336 0.848 0.983
rs4696480
B vs. A Overall 4 0.03* 1.216 (1.019–1.452) 0.990 0.085 0.218 0.754 0.969
BB vs. AA Overall 4 0.032* 1.463 (1.034–2.069) 0.556 0.145 0.337 0.848 0.983
B vs. A Caucasian 2 0.007* 1.393 (1.094–1.775) 0.725 0.029 0.084 0.501 0.910
BB vs. AA Caucasian 2 0.009* 1.903 (1.171–3.091) 0.168 0.143 0.333 0.846 0.982
BA vs. AA Caucasian 2 0.001* 1.984 (1.307–3.012) 0.095 0.040 0.110 0.576 0.932
BB+BA vs. AA Caucasian 2 0.001* 1.95 (1.317–2.887) 0.095 0.026 0.075 0.470 0.899

Statistical power was calculated using the number of observations in the subgroup and the OR and P values in this table. Abbreviations: CI, confidence interval; H-B, hospital based; HWE (Y), polymorphisms conformed to HWE in the control group.

*P-value less than 0.05 was considered as statistically significant.

The significant result with the FPRP values less than 0.2 was considered a worthy finding.