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Histological changes in kidneys (hematoxylin-eosin, × 100). (A) Normal kidney, saline group; (B and C) MTX control group increased Bowman’s capsule space and glomerular shrinkage (black arrows) and distribution of lymphocytes (green arrows), bleeding in the space between the tubules (blue arrow), and formation of adipose tissue (yellow arrow); (D) normal kidney, crocin 50 mg/kg group; (E) normal kidney structure in MTX + crocin 50 mg/kg group
