FIGURE 7.

Kidney mRNA level reduction in mice treated with 3d-8b. qPCR for the chemokines in kidneys of 22-wk-old mice described in Fig. 6 and injected at week 14 with PBS, control, and mAb 3d-8b. The bars represent (average) reduction of total RNA abundance for mAb 3d-8b–injected mice (black bar) and control Ab–injected mice (stripped bar) as compared with the mice injected with PBS only. The average ∆Cq for each mouse sample for a particular gene, either mAb 3d-8b– or control mAb–injected, was divided by the ∆Cq average for PBS-injected mice. Statistical analyses were performed by one-way ANOVA. For statistical analysis, ∆Cq for each mouse sample from mAb 3d-8b– or control Ab–injected mice was compared with ∆Cq of mice from PBS-injected group. *p < 0.05. NS, not statistically significant.