Figure 7.

Mechanisms of altered mitochondrial respiration in response to DCPIB. ETC complex isolation experiments were performed in WT (left column) and LRRC8A‐KO (right column) HAP‐1 cells with conditions as described in Figure 6 and Table 1. DCPIB significantly inhibits Complex I in (a) WT and LRRC8A‐KO cells, Complex II/III in (c) WT and (d), and Complex IV in (e) WT cells. Graphs show mean ± SEM (n = 4). Statistical analysis was carried out using student's t‐test. * Indicates p < .05