Fig. 4.

Acute treatment with C18:1 NAT decreases food intake. Male, 9-wk-old C57BL/6N mice were group-housed and given free access to HFHS diet over a 3-d sham period (anesthesia alone), 3-d treatment with i.v. 10 mg/kg C18:1 NAT or FA+Tau, and 4-d washout (n = 6 or 7). (A) Average 24-h food intake. (B) Cumulative food intake during treatment period. Arrows indicate time of treatment. (C) Weight change between study arms. (D) Average number of meals over 24 h. (E) Average meal size over 24 h. Data are presented as mean ± SEM. *P < 0.05 between treatments within study arm. ^#P < 0.05 between treatments and sham within group.