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. 2019 Nov 18;116(49):24770–24778. doi: 10.1073/pnas.1916288116

Fig. 6.

Fig. 6.

GPR119 is required for C18:1 NAT-mediated improvement in glucose tolerance but not food intake. (A) Glucose tolerance test in littermate GPR119-WT and GPR119-KO male mice after 4 wk of HFHS diet (n = 7 to 9). Arrows indicate time of treatment with 10 mg/kg C18:1 NAT or FA+Tau. (A, Insets) Area under the curve. (B–E) Plasma hormone levels after a mixed-meal challenge in HFHS diet-fed mice given a single dose of 10 mg/kg C18:1 NAT or FA+Tau (n = 7 to 9). (F) Twenty-four-hour food intake (chow) after i.v. 10 mg/kg C18:1 NAT or FA+Tau (n = 9 to 11). (G) Insulin tolerance test (ITT) in male, chow-fed FAAH-S268D x GPR119-KO (S268D-119KO) and littermate FAAH-S268D mice (n = 6 to 9). (H) GLP-1 secretion 30 min after a mixed meal (n = 7 to 11). Data are presented as mean ± SEM. *P < 0.05 between genotypes within treatment; #P < 0.05 between treatments within genotype.