Table 2.

Effects of test compounds on the regulation of LDL uptake by HepG2 cells^a.

Compd. (5 μmol/L)	DiI-LDL uptake rate (compared to vehicle, mean±SEM )
8	1.04±0.04
15	1.83±0.04∗∗
18	1.78±0.06∗∗
21	1.45±0.04∗∗
22	2.37±0.07∗∗∗
(R)-22	2.19±0.07∗∗∗
(S)-22	1.83±0.03∗∗
24	1.62±0.05∗∗
Berberine	1.38±0.03*
Vehicle	1.00±0.02

^aEffects of test compounds on the regulation of LDL uptake by HepG2 cells. HepG2 cells were treated with test compounds (5 μmol/L) for 24 h. Then the culture medium was changed to DMEM supplemented with 2% LPDS and 20 μg/mL DiI-LDL for another 4 h incubation. DiI-LDL uptaken by HepG2 cells was extracted by isopropanol and measured by microplate reader. Results are shown as mean ± SEM of three independent experiments. *P < 0.05; ^∗∗P < 0.01; ^∗∗∗P < 0.001; as compared to the vehicle group.