Table 3.

Selectivity of six compounds on the typical biological targets of berberine^a.

Compd.	IC50 (μmol/L)
	β1	D1	D2	5-HT1B
8	>100	5.56±0.08	17.87±0.86	47.16±1.22
15	>100	1.61±0.13	>100	40.83±0.80
18	∼100	1.71±0.10	>100	>100
21	∼100	2.35±0.07	∼50	>100
22	>100	∼100	>100	13.43±0.51
24	>100	>100	>100	15.70±0.59
Berberine	–	15.5b	17.1b	–

‒Not applicable.

^aValues are the average of 3 independent experiments. β₁, beta-1 adrenergic receptor antagonist activity; D₁, dopamine D₁ antagonist activity; D₂, dopamine D₂ antagonist activity; 5-HT_1B, serotonin 5-HT_1B receptor antagonist activity.

^bRef. 21.