Table 2.

Endogenous and exogenous substrates of UGTs and ligands of transcription factors.

Family	Enzyme	Endogenous substrate	Xenobiotic substrate	Transcription factor
UGT1A	UGT1A1	Bilirubin, estradiol, fatty acids	SN-38, leonurine, bergenin, axitinib	CAR, PXR, PPARα, AhR43, NRF2
	UGT1A3	Bile acid, arachidonic	Polyaromatic amines, non-steroidal anti-inflammatory drugs, statins, ahydroxygenkwanin, genkwanin, ursolic acid44, fimasartan45, alpinetin23	PPARα, HNF1, AhR, LXR, PXR
	UGT1A4	Eicosanoids	Imipramine, lamotrigine, clonazolam, deschloroetizolam, etizolam, flubromazolammetizolam	HNF1, PPARα, PXR, CAR, AhR, HNF1α
	UGT1A6	Serotonin	1-Naphthol 4-nitrophenol	AhR, CAR, PXR, PPARα
	UGT1A7	Unknown	Icaritin, carcinogens	AhR, HNF1, HNF4α, NRF2
	UGT1A8	Fatty acids	Retinoids, catechol estrogens, opioids, coumarins, flavonoids, anthraquinones, phenols, raloxifene	HNF1, HNF4α, AhR, NRF2
	UGT1A9	Steroids, fatty acids	Bulky phenols, propofol, mycophenolic acid, niflumic acid, psoralidin	CAR, HNF1, HNF4α, PPARα, AhR, NRF2
	UGT1A10	Estrogens	Nitrosamine, flavonoids, polycyclic aromatic hydrocarbons, raloxifene, dopamine	HNF1α, HNF4α, AhR, NRF2
UGT2A	UGT2A2/3	Hyodeoxycholic acid	Tobacco carcinogen	HNF1, LXR
UGT2B	UGT2B4	Arachidonic acid	Naftopidil, deoxynivalenol	PPARα, AhR, FXR
	UGT2B7	Sex-steroid hormones, glucocorticoids, mineralocorticoid, bile acids	Naftopidil, deoxynivalenol, mirabegron, efavirenz, zidovudine, codeine, morphine	HNF1α46, CAR, PXR, FXR, PPAR, NRF2
	UGT2B10	Eicosanoids	Amitriptyline, imipramine, clomipramine, trimipramine	CAR, FXR, AR
	UGT2B11	Unknown	3a-Hydroxyandrogens, 3a-pregnanes, Hydroxylestrogens	ER, AR
	UGT2B15	Sex-steroid hormones	Oxazepam, lorazepam, sipoglitazar, bisphenol-A	AR, ER, HNF3α, FXR
	UGT2B17	Sex-steroid hormones	Coumarins, anthraquinones flavonoids, chlorantraniliprole	HNF1α, HNF4α, HNF3α, AR, ER
	UGT2B28	Sex-steroid hormones	Unknown	ER, AR
UGT3	UGT3	Unknown	N-Acetylglucosamine	Unknown
UGT8	UGT8A1	Bile acids	Unknown	LXR