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. 2019 Nov 20;116(49):24779–24785. doi: 10.1073/pnas.1914163116

Fig. 4.

Fig. 4.

Deconstruction of signatures of unique mutations in BCL6 SE (A) and IgHV3-23 (B) from 10 merged B cell samples using deconstructSigs (24). Panels represent the original profiles (A-1 and B-1), the signature as computed using the best-fitting combination of COSMICv3 SBS signatures (A-2 and B-2), the difference between the preceding 2 figures (A-3 and B-3), and the breakdown of the original profile into COSMIC v3 SBS signatures (A-4 and B-4). Types of base substitutions and the array of trinucleotide motifs are displayed; motifs with the most frequent substitutions found in the original profile (panel 1) are highlighted with colors designated for each of the six base substitution types.