Table 2.
Associations of vitamin D3 concentration and MS stratified by biobank and age.
| Vitamin D categories | Cut-off nmol/L |
Number of (%) |
OR | 95% CI | ||
|---|---|---|---|---|---|---|
| Cases | Controls | |||||
| Biobank | ||||||
| Umeå | Quintile 1–4 | 38, 48, 59 | 90 (88.2) | 81 (79.4) | ref | |
| Quintile 5 | ≥73 | 12 (11.8) | 21 (20.6) | 0.47 | 0.20–1.1 | |
| PHAS | Quintile 1–4 | 37, 50, 63 | 114 (83.2) | 109 (79.6) | ref | |
| Quintile 5 | ≥82 | 23 (16.8) | 28 (20.4) | 0.75 | 0.38–1.5 | |
| Örebro | Quintile 1–4 | 35, 48, 60 | 26 (89.7) | 23 (79.3) | ref | |
| Quintile 5 | ≥72 | 3 (10.3) | 6 (20.7) | 0.40 | 0.08–2.1 | |
| Göteborg | Quintile 1–4 | 41, 50, 59 | 41 (87.2) | 37 (78.7) | ref | |
| Quintile 5 | ≥71 | 6 (12.8) | 10 (21.3) | 0.43 | 0.11–1.7 | |
| Skåne | Quintile 1–4 | 38, 47, 58 | 252 (81.0) | 248 (79.7) | ref | |
| Quintile 5 | ≥73 | 59 (19.0) | 63 (20.3) | 0.90 | 0.58–1.4 | |
| Linköping | Quintile 1–4 | 27, 42, 55 | 37 (94.9) | 31 (79.5) | ref | |
| Quintile 5 | ≥70 | 2 (5.1) | 8 (20.5) | 0.25 | 0.05–1.2 | |
| All | Quintile 1–4 | 560 (84.2) | 529 (79.5) | ref | ||
| Quintile 5 | 105 (15.8) | 136 (20.5) | 0.68 | 0.50–0.93 | ||
| Alla | Quintile 1 | 134 (20.1) | 133 (20.0) | ref | ||
| Quintile 2 | 142 (21.4) | 133 (20.0) | 1.1 | 0.77–1.5 | ||
| Quintile 3 | 131 (19.7) | 130 (19.5) | 0.99 | 0.71–1.4 | ||
| Quintile 4 | 153 (23.0) | 133 (20.0) | 1.1 | 0.78–1.6 | ||
| Quintile 5 | 105 (15.8) | 136 (20.5) | 0.72 | 0.49–1.1 | ||
| Age group | ||||||
| <20 | Quintile 1–4 | 126 (88.7) | 118 (83.1) | ref | ||
| Quintile 5 | 16 (11.3) | 24 (16.9) | 0.60 | 0.29–1.2 | ||
| 20–29 | Quintile 1–4 | 313 (83.7) | 297 (79.4) | ref | ||
| Quintile 5 | 61 (16.3) | 77 (20.6) | 0.70 | 0.46–1.1 | ||
| 30–39 | Quintile 1–4 | 121 (81.2) | 114 (76.5) | ref | ||
| Quintile 5 | 28 (18.8) | 35 (23.5) | 0.72 | 0.39–1.3 | ||
MS: multiple sclerosis; OR: odds ratio; CI: confidence interval; PHAS: Public Health Agency of Sweden.
aIn the total cohort, P for trend over quintiles was 0.24.