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. 2019 Sep 3;25(8):473–486. doi: 10.1177/1753425919871994

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© The Author(s) 2019

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — A proposed model for monocyte/macrophage-dependent survival of neutrophils. 1. Neutrophil recruitment from blood to a site of Gram-negative bacterial infection involves adherence to extracellular matrix proteins during and after extravasation. 2. TLR4 signaling in adherent neutrophils is uncoupled from ERK activation and anti-apoptotic outcomes. 3. Neutrophil survival becomes dependent on survival factors secreted by TLR4-stimulated monocyte/macrophages. 4. Upon clearance of infection monocyte/macrophages stop secreting survival factors for proximal neutrophils, which are cleared through efferocytosis to initiate inflammation resolution.