Table 3.
Factor XI Deficient Women Receiving Neuraxial Anesthesia.
| ID | Severity | Pregnancy | FXIa | aPTTa | Anesthesia | Plasma and/or Antifibrinolytic |
|---|---|---|---|---|---|---|
| 1 | Partial | 1/1 | 69 | – | Spinal | n |
| 2 | Severe | 1/2 | – | – | Epidural | n |
| 3 | Partial | 1/5 | – | – | Epidural | n |
| 2/5 | – | – | Epidural | n | ||
| 3/5 | – | – | Epidural | n | ||
| 4/5 | 42 | 32 | Epidural | n | ||
| 5/5 | 45 | 30.4 | Epidural | n | ||
| 4 | Severe | 1/2 | <1 | 60 | Spinal | 2200cc (30 mL/kg) plasma, TXA |
| 2/2 | 2 | 61.4 | Spinal | 1100cc (14.5 mL/kg) plasma, EACA | ||
| 5 | Partial | 1/3 | – | – | Epidural | n |
| 2/3 | 52 | 31.7 | Epidural | n | ||
| 6 | Partial | 1/1 | 40 | 31.1 | Spinal | n |
| 7 | Partial | 1/2 | – | – | Epidural | n |
| 2/2 | 36 | 32.3 | Epidural | n | ||
| 8 | Partial | 2/2 | 50 | 32 | Epidural | n |
| 9 | Partial | 4/8 | – | – | Epidural | n |
| 10 | Partial | 1/1 | 48 | 28 | Epidural | n |
| 11 | Partial | 1/4 | – | – | Epidural | n |
| 12 | Partial | 4/4 | 44 | 33.9 | Spinal | n |
| 13 | Severe | 1/1 | 7 | 39.9 | Epidural | 1320cc (17.1 mL/kg) plasma |
| 14 | Partial | 1/1 | 46 | 29.7 | Spinal | N |
| 15 | Partial | 1/3 | – | 27.7 | Epidural | n |
| 3/3 | 48 | 27 | Spinal + Epidural | n | ||
| 16 | Partial | 1/1 | 59 | 27.7 | Epidural | n |
| 17 | Partial | 2/2 | 63 | 28.3 | Epidural | n |
| 18 | Partial | 2/2 | 48 | 30.7 | Epidural | n |
| 19 | Partial | 1/1 | 50 | 32 | Epidural | n |
| 20 | Partial | 1/1 | 49 | 27.1 | Epidural | n |
| 21 | Partial | 1/1 | 42 | 29.9 | Epidural | n |
| 22 | Severe | 2/2 | 15 | 34.9 | Epidural | n |
| 23 | Partial | 1/1 | 55 | 29 | Epidural | n |
| 24 | Partial | 1/1 | 44 | 30.2 | Epidural | n |
Abbreviations: aPTT, activated partial thromboplastin time (seconds); EACA, aminocaproic acid; FXI, Factor XI Activity (IU/dL); TXA, tranexamic acid.
a Third trimester value.