Table 1.
Top 10 hub genes of key modules in the ovariectomized control and ovariectomized estrogen-treated co-expression networks.
| Brown | Green | Grey 60 | Light Cyan | Midnight Blue | Pink | Red | Tan | Turquoise | Yellow |
|---|---|---|---|---|---|---|---|---|---|
| Top 10 hub genes in key modules of the OC co-expression network | |||||||||
| Uck2 | Angptl1 | Gm3002 | Hmgb1 | Gnpnat1 | D5Ertd577e | Myof | Rpl29 | Acad11 | Abca2 |
| Nup205 | Gpc4 | Gm10406 | Hmgb1-ps7 | Sgpp1 | E330014E10Rik | Serp1 | Gm8580 | Sucla2 | Tmem248 |
| Slc3a2 | Sparcl1 | Gm3696 | Rps6 | Pddc1 | Clec3a | Plxnb2 | Rpl28 | Pdpr | 9130011E15Rik |
| Sh3bp2 | Plagl1 | 4930555G01Rik | Tcp1 | Sptssa | C87414 | Ms4a7 | Pnlip | Fam120c | Smcr7l |
| Pdpn | H19 | D830030K20Rik | Srsf5 | Scarb1 | 9330020H09Rik | Yipf1 | Gm10548 | Tmem143 | Slc25a38 |
| Pold3 | Pamr1 | Gm5458 | Tgds | Tmem67 | Gm5622 | Slc25a24 | Phb2 | Ppp6r2 | Dnajb2 |
| Pcna | Itm2a | Gm5796 | Wtap | Pofut2 | Magea3 | Rps12 | Gsto1 | Fyco1 | Herpud2 |
| Clptm1l | Nrk | Gm2897 | Snora44 | Dynlt1a | Cecr6 | Tmem173 | Spry3 | Man2a2 | Vprbp |
| Upp1 | Ssc5d | Pfn4 | Chic2 | Nme4 | Muc19 | Nucb2 | Rag1 | Socs7 | Smg5 |
| Ubash3b | Antxr1 | Tex9 | Klhl41 | Mbip | Gpr142 | Anxa1 | Mrps2 | Obscn | Cog1 |
| Top 10 hub genes in key modules of the OE co-expression network | |||||||||
| Tspan4 | Fam198b | Gm10406 | Hmgb1 | Dzip3 | Spata20 | Bcat1 | Rpl29 | Mpc2 | 9130011E15Rik |
| Pcna | Gbp6 | Gm3002 | Hmgb1-ps7 | Armcx2 | Ttc16 | Actn1 | Gm8580 | Coq5 | Hook1 |
| Gm6377 | Cdon | 4930555G01Rik | Khdrbs1 | Akt3 | Taf7l | Kdelr2 | Elovl4 | Tmtc1 | Ttll7 |
| Lpxn | Hmcn1 | Gm3696 | Rps3a1 | Fchsd2 | Rbp2 | Rnf26 | Rpl28 | Cacna2d1 | Pdpk1 |
| Plek | Gpc6 | D830030K20Rik | Skap2 | Slc2a10 | Megf6 | Iqgap2 | Atp6v0c | Cep68 | Msl3 |
| Anxa4 | Antxr1 | Gm5458 | Ubash3b | Slc36a4 | Crygc | Entpd1 | Gjb5 | Klhl7 | 9630033F20Rik |
| Capg | Tmem131 | Gm5796 | Apbb1ip | Cntln | Ttll10 | Stil | Alg3 | Fbxo9 | Ank3 |
| Tlr13 | Islr | Gm2897 | Rpl15 | Casp2 | Chgb | Gnai2 | Ftl1 | Insr | Tom1l2 |
| Cndp2 | Ttc3 | Mir376a | Rasgef1b | Eogt | Fbxo3 | Ccnf | Hid1 | Pdpr | Lmtk2 |
| Aprt | Plagl1 | Tspan12 | Hnrnpd | Ska2 | Nphs1 | Cdc25b | Scamp4 | Acad11 | Rora |
Note: These are the 10 most centrally located genes from key modules identified during weighted correlational gene network analysis of mRNA expression. Key modules were identified as those with any significant correlation with post injury time or RelUHW.
OC: ovariectomized control; OE: ovariectomized estrogen-treated; RelUHW: relative uterine horn weight (calculated as uterine horn weight divided by necropsy weight); Bold: hub genes common between both networks.