Table 2.
Functionally enriched pathways by module and post-crush time.
| Modules |
Significant post-crush time correlations (P-value) |
Functionally enriched pathway themes (total number significantly enriched clusters) | ||
|---|---|---|---|---|
| 32 h | 96 h | 192 h | ||
| OC Brown | r = −0.67 (P = 0.002) | r = 0.7 (P = 0.001) | Smooth endoplasmic reticulum, protein folding, transport, stabilization; neutrophil, lymphocyte, monocyte chemotaxis (8) | |
| OC Green | r = 0.21 (P = 0.03) | r = −0.71 (P = 0.001) | Proteostatic functions including proteolysis (6) | |
| OC Grey 60 | r = −0.49 (P = 0.04) | Immune cell chemotaxis, chemokine and cytokine signaling (5) | ||
| OC Pink | r = −0.5 (P = 0.04) | (0) | ||
| OC Red | r = −0.58 (P = 0.01) | Microtubules, microtubule-related movement, nucleosomes (13) | ||
| OC Tan | r = 0.5 (P = 0.03) | Glucose homeostasis, aerobic respiration (3) | ||
| OC Turquoise | r = 0.64 (P = 0.005) | Phagocytosis, natural killer cell mediated cytotoxicity, apoptotic signaling, chemotaxis (15) | ||
| OC Yellow | r = −0.53 (P = 0.02) | r = 0.63 (P = 0.005) | tRNA binding, collagen organization, proteasome function, translation initiation (4) | |
| OE Brown | r = −0.6 (P = 0.006) | r = 0.51 (P = 0.03) | Endoplasmic reticulum function, stress responses; chemotaxis of macrophages, neutrophils, eosinophils, monocytes (9) | |
| OE Grey 60 | r = 0.62 (P = 0.006) | Chemotaxis of macrophages, neutrophils, eosinophils, monocytes; limb morphogenesis, mesenchymal cell proliferation regulation (6) | ||
| OE Light Cyan | r = −0.48 (P = 0.04) | r = 0.54 (P = 0.02) | Arp2/3 protein complex, Arp2/3 mediated actin nucleation; chemotaxis of macrophages, neutrophils, eosinophils, monocytes (16) | |
| OE Midnight Bluea | r = 0.51 (P = 0.03) | Protein palmitoylation processes, cell projection organization, cilium morphogenesis (6) | ||
| OE Reda | r = −0.57 (P = 0.01) | r = 0.62 (P = 0.006) | Microtubules, microtubule-related movement, TCA Cycle, nucleosomes (9) | |
| OE Turquoise | r = 0.57 (P = 0.01) | Glycogen metabolism, glucagon signaling processes, oxidative phosphorylation, nucleosomes (9) | ||
OC: ovariectomized control; OE: ovariectomized estrogen-treated; RelUHW: relative uterine horn weight (calculated as uterine horn weight divided by necropsy weight).
a
Significant correlation with RelUHW [OE Midnight Blue: r = −0.06, P = 0.009; OE Red: r = −0.059, P = 0.009.