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. 2019 Nov 20;116(49):24527–24532. doi: 10.1073/pnas.1915442116

Fig. 1.

Fig. 1.

Serum calcium of mice during the depletion period. DBP+/+ and DBP−/− were equally hypocalcemic after a period of alternating dietary calcium with no dietary vitamin D. Mice were weaned at 3 wk of age and were placed on purified, vitamin D-free diets with alternating dietary calcium content. On study week 1, they were fed an adequate (0.47% Ca) calcium, vitamin D-free diet for 1 wk followed by 3 wk on the same diet but containing no added calcium (0.02% Ca). This procedure was repeated once for DBP−/− mice (weeks 1–8), after which they were maintained on the adequate calcium, vitamin D-free diet until week 12. The procedure was repeated twice for DBP+/+ mice in order to ensure mice reached the same level of hypocalcemia (weeks 1–12). Blood was collected for calcium analysis after 1 wk on each diet (n = 14, ± SEM, *P < 0.05 vs. DBP+/+).