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. 2019 Nov 20;116(49):24527–24532. doi: 10.1073/pnas.1915442116

Fig. 2.

Fig. 2.

UVB treatment failed to correct hypocalcemia and circulating 25(OH)D levels in vitamin D-deficient DBP−/− mice. Mice were made vitamin D-deficient and hypocalcemic as described under Experimental Mice. Animals were irradiated once daily for 4 d. Blood was collected for calcium analysis 24 h after each treatment. (A) Repeated UVB treatment normalized serum calcium in vitamin D-deficient DBP+/+ mice but had no effect on DBP−/− mice. Dotted line indicates end of UV treatment. One- and 2-wk timepoints represent serum calcium 1 wk and 2 wk following cessation of UVB treatment (n = 5 for DBP+/+ mice, n = 6 for DBP−/− mice, ± SEM, *P < 0.05 vs. DBP+/+). (B) At the end of the treatment period, serum 25(OH)D levels were undetectable in DBP−/− mice. Blood was collected for serum 25(OH)D measurement 24 h after the final treatment (n = 3 for DBP+/+ mice, n = 2 pools of 2 DBP −/− mice, ± SEM, *P < 0.05 vs. DBP+/+).