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Receiver operating characteristic and area under the curve (AUC) of plasma cell-free DNA (cfDNA) concentrations (A) and cfDNA-integrity index (B) to distinguish patients with distant metastasis from other patients and controls. The AUC for cfDNA concentrations and the cfDNA integrity index was 0.833 (95% CI: 0.714–0.952; p = 0.002) and 0.752 (95% CI: 0.611–0.893; p < 0.001), respectively.
