Comparison of cell-free DNA (cfDNA) and cfDNA integrity index according
to treatment response: cfDNA levels (solid line) and the cfDNA integrity
index (dotted line) at various time points in 6 patients. The vertical
axis on the left represents cfDNA concentration, and the vertical axis
on the right represents the cfDNA integrity index. The horizontal axis
labels represent the times of plasma-sampling day and tumor status.
A. Patient 1, transitional carcinoma of the bladder
treated with surgery and cyclooxygenase-2 inhibitor; B.
Patient 2, undifferentiated sarcoma treated with surgery;
C. Patient 3, splenic hemangiosarcoma treated with
surgery and chemotherapy; D. Patient 4, lymphoma treated
with chemotherapy; E. Patient 5, lymphoma treated with
chemotherapy; F. Patient 6, leukemia treated with
chemotherapy. CR = complete response; PD = progressive disease; PR =
partial response.