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AUC of cfDNA and the DNA integrity index for screening distant metastasis.
| cfDNA | DNA integrity index | |
|---|---|---|
| AUC (95% CI) | 0.833 (0.714–0.952) | 0.752 (0.611–0.893) |
| Cutoff value | 852 ng/mL | 0.62 |
| Accuracy (%) | 84.1 | 71.4 |
| Sensitivity (%) | 73.7 | 63.2 |
| Specificity (%) | 88.6 | 81.8 |
| PPV (%) | 73.7 | 52.0 |
| NPV (%) | 88.6 | 84.2 |
AUC = area under the receiver operating characteristics curve; cfDNA = cell-free DNA; CI = confidence interval; NPV = negative predictive value; PPV = positive predictive value.
