Figure 2.

Irradiation Induces Dynamic Changes in the Transcription Profile of BM ECs

(A) Heatmap of selected EC-enriched genes in BM cells, Lin^– cells, LSK cells, ECs, irradiated ECs (9 Gy, 7 days), Lepr⁺, and NG2⁺ cells.

(B) PCA plot of control and irradiated ECs together with other BM cell types. Data for Lepr⁺ and NG2⁺ cells were previously published (Asada et al., 2017).

(C) Sample distance analysis of different BM cell types, as indicated.

(D and E) PCA plot (D) and sample distance analysis (E) of ctrl ECs and ECs at 1 day or 7 days after irradiation.

(F–H) MA plot showing differentially expressed genes (red dots) between Ctrl ECs and ECs at 7 days after irradiation (9 Gy) (F), Ctrl ECs and ECs at 1 day after irradiation (G), and ECs at 1 and 7 days after irradiation (H), as indicated.

(I) Heatmap of selected HSC niche-related genes after irradiation.

See also Figure S2.