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. 2019 May 8;20(Suppl 3):293. doi: 10.1186/s12864-019-5539-y

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© The Author(s). 2019

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 7 — Analysis of evolutionary conservation of c-FLIP/NEMO binding sites. Phylogeny of the species and time points of the lineage diversification calculated using TimeTree database [23] are shown on the top of the figure. Background of the branches is colored based on predicted binding energy of c-FLIP and NEMO using FoldX. Reference organism names and predicted binding energies are indicated. Blue color gradient indicates an increase of stability of a complex in comparison with human complex; Red gradient indicates a decrease in stability. Silhouette images were obtained from PhyloPic (http://phylopic.org). The sequence alignments of NEMO and c-FLIP binding site regions are shown on the bottom of the figure. Arrows indicate amino acid residues located on the binding site interface of c-FLIP and NEMO