Table 1.
Clinicopathologic factors based on timing of RIOT readiness*
| Factor | Total | Early RIOT | Delayed RIOT | P value |
|---|---|---|---|---|
| No. of patients | 114 | 82 | 32 | |
| Preoperative | ||||
| Age | 55 (46, 62) | 54 (46, 61) | 57 (44, 66) | 0.285 |
| Gender, female | 57 (50) | 42 (51) | 15 (47) | 0.835 |
| BMI (kg/m2) | 26 (24, 32) | 27 (24, 32) | 26 (23, 29) | 0.255 |
| ECOG performance status | 0.381 | |||
| 0 | 51 (45) | 40 (49) | 11 (34) | -- |
| 1 | 61 (54) | 40 (49) | 21 (66) | -- |
| 2 | 1 (1) | 1 (1) | 0 (0) | -- |
| 3 | 1 (1) | 1 (1) | 0 (0) | -- |
| Use of opioids | 17 (15) | 11 (13.4) | 6 (19) | 0.560 |
| Use of blood thinners | 17 (15) | 9 (11) | 8 (25) | 0.079 |
| Weight loss | 5 (4) | 2 (2) | 3 (9) | 0.134 |
| Cirrhosis | 7 (6) | 5 (6) | 2 (6) | 1.000 |
| Preoperative chemotherapy | 60 (53) | 44 (54) | 16 (50) | 0.835 |
| Hemoglobin (gm/dL) | 13.1 (12.1, 14.3) | 13.2 (12.1, 14.3) | 12.9 (11.6, 13.9) | 0.379 |
| White blood cell count (K/uL) | 5.6 (4.7, 7.3) | 5.5 (4.6, 7.1) | 5.9 (5.0, 7.6) | 0.137 |
| Neutrophil/Lymphocyte ratio | 2.3 (1.6, 3.5) | 2.3 (1.6, 3.3) | 2.8 (1.9, 3.8) | 0.258 |
| Platelet count (K/ul) | 214 (165, 259) | 212 (167, 260) | 222 (163, 260) | 0.726 |
| Albumin (gm/dL) | 4.3 (4.1, 4.5) | 4.3 (4.1, 4.5) | 4.2 (4.0, 4.5) | 0.062 |
| Severe symptom burden** | 24 (27) | 13 (20) | 11 (44) | 0.024 |
| Perioperative | ||||
| Open approach | 76 (67) | 46 (56) | 30 (94) | <0.001 |
| Major hepatectomya | 32 (28) | 17 (21) | 15 (47) | 0.006 |
| Number of liver tumors | 1 (1, 3) | 1.5 (1, 3) | 1 (1, 4) | 0.267 |
| Largest tumor diameter | 3.1 (1.5, 5.2) | 2.4 (1.3, 4.5) | 5.9 (2.8, 8.6) | <0.001 |
| Multivisceral operation | 19 (17) | 10 (12) | 9 (28) | 0.052 |
| Postoperative transfusion | 6 (5) | 6 (7) | 0 (0) | 0.183 |
| Length of stay (days) Postoperative |
5 (3, 6) | 4 (3, 5) | 6 (5, 8) | <0.001 |
| Postoperative | ||||
| Any complication | 22 (19) | 11 (13) | 11 (34) | 0.011 |
| Major complicationb | 6 (5) | 3 (4) | 3 (9) | 0.347 |
| Bile leak | 10 (9) | 5 (6) | 5 (16) | 0.140 |
| Emergency Room visitc | 12 (11) | 5 (6) | 7 (22) | 0.036 |
| Wound infection | 7 (6) | 2 (2) | 5 (16) | 0.018 |
*
Values are reported as number (percentage) or median (interquartile range [IQR])
**
This data was available for 89 (78%) patients, 64/82 Early RIOT patients and 25/32 Delayed RIOT patients. Severe symptom burden was defined as MDASI-GI symptom or symptom interference score 7/10.
a
Defined as resection of ≥3 contiguous liver segments
b
Accordion Severity Grading System, Grade ≥ 3
c
Within 30 days of the operation
RIOT, return to intended oncologic therapy; BMI, body mass index; ECOG, Eastern Cooperative Oncology Group