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. 2019 Dec 2;10:2780. doi: 10.3389/fimmu.2019.02780

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Copyright © 2019 Hickman, Allison, Coleman, Kingery-Gallagher and El Khoury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CX3CR1 deficiency results in reduced Aβ deposits and levels of Aβ in 10-month old PS1-APP-CX3CR1-deficient genotypes. (A–C) Fixed brain sections from 10-month old PS1-APP, PS1-APP-CX3CR1^+/−, and PS1-APP-CX3CR1^−/− mice were stained using polyclonal pan-Aβ antibody. The number of Aβ deposits (A) and Aβ-deposit area fraction (B) were determined using three sections per mouse (Values represent group mean ± SEM). (C) Quantitative PCR measurements of CX3CR1 RNA in 10-month old PS1-APP, PS1-APP-CX3CR1^+/−, and PS1-APP-CX3CR1^−/− microglia show a gene dosage effect. (D) Representative fluorescent micrographs of plaques (red) in PS1-APP, PS1-APP-CX3CR1^+/−, and PS1-APP-CX3CR1^−/− mice. For all measurements in this figure, n = 6 for PS1-APP, n = 7 for PS1-APP-CX3CR1^+/−, and n = 3 for PS1-APP-CX3CR1^−/−. * represent statistically significant.