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. 2019 Dec 2;10:2780. doi: 10.3389/fimmu.2019.02780

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Copyright © 2019 Hickman, Allison, Coleman, Kingery-Gallagher and El Khoury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Partial CX3CR1 deficiency affects Aβ levels but does not affect total microglial numbers or the numbers of plaque-associated microglia. Quantification of (A) Aβ (1-42) and (B) Aβ (1-40) by ELISA in brain homogenates of 10-month old mice (Numbers represent mean ng of Aβ/mg brain ± SEM). (C) Quantification of total number of microglia isolated per hemisphere. (D) Quantification of the number of CD11b+ cells associated per plaque ≥75 μm in diameter. (E) Representative micrographs of plaques (green) and microglia (brown) in PS1-APP and PS1-APP-CX3CR1^+/− mice. For all measurements in this figure, n = 6 for PS1-APP, n = 7 for PS1-APP-CX3CR1^+/−. For (E) 80 plaques were counted per genotype. * represent statistically significant.