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. 2019 Dec 2;10:2780. doi: 10.3389/fimmu.2019.02780

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Copyright © 2019 Hickman, Allison, Coleman, Kingery-Gallagher and El Khoury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CX3CR1 deficiency results in reduced plaque-load in 5- and 24-month old PS1-APP-CX3CR1^+/− mice. (A,B) Brain sections from PS1-APP and PS1-APP-CX3CR1^+/− mice at 5 and 24-months of age were stained and Aβ area fraction (AβAF) was determined for hippocampus + cortex in mice at 5 and 24-months of age. (A) At 5 months of age AβAF is significantly reduced in PS1-APP-CX3CR1^+/− (n = 3) mice compared with PS1-APP mice (n = 8). (B) At 24- months of age, AβAF is also significantly reduced in PS1-APP-CX3CR1^+/− (n = 5) mice compared with PS1-APP mice (n = 6). For all groups three sections per mouse were quantified and numbers represent group mean ± SEM. * represent statistically significant.