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. 2019 Dec 2;10:2780. doi: 10.3389/fimmu.2019.02780

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Copyright © 2019 Hickman, Allison, Coleman, Kingery-Gallagher and El Khoury.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of CX3CR1 deficiency on expression of IDE and MMP9 in microglia from WT, PS1-APP, and PS1-APP-CX3CR1^+/− mice. Expression of IDE (A) MMP9 (B) was analyzed by qPCR on RNA isolated from microglia freshly harvested from brains of PS1-APP, WT littermates, and PS1-APP-CX3CR1^+/− mice at 24 months of age: WT brain (n = 6), WT microglia (n = 6), PS1-APP (n = 10), and PS1-APP-CX3CR1^+/− (n = 6). Levels of enzymes are expressed relative to the β2M housekeeping gene and bars represent mean ± SEM. * represent statistically significant.