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. 2019 Dec 2;10:2780. doi: 10.3389/fimmu.2019.02780

Figure 7.

Figure 7

PS1-APP-CX3CR1+/− mice perform better that PS1-APP in the Barnes maze behavioral test. Mice at 10-months of age were first trained for 5 days on cued-target Barnes maze and then data collected during a 4-day training using hidden-fixed target protocol on Barnes maze. Escape latency, which is the time for a subject to locate and enter the escape box, was collected for each mouse during all trials and is shown in (A) for Days 1 and 4 of the hidden-fixed target Barnes maze protocol (mean escape latency in s ± SEM). On Day 1 there were no significant differences in escape latencies between genotypes. By Day 4, PS1-APP animals took significantly longer to escape the maze compared with both WT and PS1-APP-CX3CR1+/− mice. (B) Shows representative maze tracings for each genotype on Day 4 of the hidden-fixed target protocol. Animal numbers are WT (n = 6), PS1-APP (n = 8) and PS1-APP-CX3CR1+/− (n = 6). * represent statistically significant.