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. 2019 Dec 2;10:1428. doi: 10.3389/fphar.2019.01428

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Copyright © 2019 Zhong, Wang, Zhang, Yuan, Hu, Xiong, Zheng, Liu, Xu, Xiao, Wu and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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aFGF treatment attenuates 6-OHDA-induced PD via inhibiting ER stress. (A) The number of rotations (turns/min) on the affected side of rats during rotational behavior test, n = 12. ^#### P < 0.0001: aFGF group vs. 6-OHDA group; ****P < 0.0001: 4-PBA group vs. 6-OHDA group. (B) H&E staining of striatum region, Nissl staining of nigral region, and immunohistochemistry staining results of TH and α-syn expression in striatum region. Scale bar = 50 μm, n = 6. (C, D) Quantitative analysis of immunohistochemistry staining results of TH and α-syn expression in striatum region. (E) Western blot results of TH, α-syn and FGFR1 expressions. (F–H) Quantitative analysis results of TH, α-syn, and FGFR1 expressions, *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. the other group, n = 6.