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. 2019 Dec 2;10:1428. doi: 10.3389/fphar.2019.01428

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Copyright © 2019 Zhong, Wang, Zhang, Yuan, Hu, Xiong, Zheng, Liu, Xu, Xiao, Wu and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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aFGF suppresses the pro-apoptotic protein of TRB3 and subsequently activates autophagy via inhibiting CHOP expression during PD development. (A–C) Immunohistochemical image and quantitative analysis of CHOP and TRB3 expressions in the substantia nigra of the affected side. Scale bar = 50 μm, n = 6. (D) Western blot results of CHOP and TRB3 expressions. (E, F) Quantitative analysis of CHOP and TRB3 expressions. *P < 0.05, **P < 0.01, ***P < 0.001 vs. the other group, n = 6.