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. 2019 Dec 2;10:1428. doi: 10.3389/fphar.2019.01428

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Copyright © 2019 Zhong, Wang, Zhang, Yuan, Hu, Xiong, Zheng, Liu, Xu, Xiao, Wu and Ye

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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aFGF treatment ameliorates 6-OHDA-induced neuronal death via suppressing TRB3 expression. (A) Representative images of TUNEL staining (green) of PC12 cells under 6-OHDA treatment. (B) Quantitative analysis of TUNEL-positive cells, Scale bar = 50 μm, n = 5. (C–F) Representative fluorescence images and quantitative analysis of CHOP and TRB3 expressions in PC12 cells. Scale bar = 50 μm, n = 5. (G) Western blot results of GRP78, CHOP, and TRB3 expressions in PC12 cells. (H–J) Quantitative analysis results of GRP78, CHOP, and TRB3 expressions in PC12 cells, n = 3. *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 vs. the other group.