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. 2019 Dec 9;15(12):e8831. doi: 10.15252/msb.20198831

Figure 1. Chemical genomic screen across four Saccharomyces cerevisiae strains.

Figure 1

  1. Core genome phylogeny of part of the Saccharomyces Genome Resequencing Project (SGRP) yeast isolates; coloured dots indicate the four strains whose KO library was screened in this study.
  2. Schematic of the chemical genomic screen; each strain's KO library was robotically plated on 1,536 solid agar plates, and each KO colony size was used as a proxy for fitness in each condition.
  3. Reproducibility of the S‐scores using the two batches used in the screening.
  4. Reproducibility of the S‐scores using genes having multiple independent colonies plated in the screening.
  5. Clustered heatmap of the whole chemical genomic screen; each subsection belongs to an individual strain's KO library. Grey cells indicate missing values.