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. 2019 Dec 9;15(12):e8831. doi: 10.15252/msb.20198831

Figure 4. Genes linked to growth phenotypes via GWAS analysis in 925 natural yeast isolates.

Figure 4

  • A
    S‐score heatmap of the yeast natural isolates across 34 conditions that were also used in the KO screening.
  • B
    Number of variants significantly associated (P < 1E‐6) with phenotypic variation in each growth condition.
  • C
    Number of associated variants that overlap (i.e. are in a 3‐kbp window) with a conditionally essential gene in the same condition, in any of the four KO libraries.
  • D–G
    Manhattan plots showing examples of overlaps between associated variants and the KO screening. The top plot shows the associations between variants and growth in the natural isolates as a function of the −log10 of the association P‐value, while the four bottom plots show the strength of the KO phenotypes across the four yeast strains, as a function of the −log10 of the corrected S‐score P‐value. Sections shaded in grey indicate the overlap between associations and KO data. Position in the yeast chromosome is reported in kilobase units.