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. Author manuscript; available in PMC: 2020 Nov 1.
Published in final edited form as: Paediatr Perinat Epidemiol. 2019 Oct 28;33(6):490–502. doi: 10.1111/ppe.12592

Table 3.

Study populations, the PrePARED Consortium

STUDY AGE RANGE STUDY FOCUS STUDY POPULATION DESCRIPTION N
Reproductive-aged women
Australian Longitudinal Study on Women’s Health 18–27 for the 1989–95 cohort (baseline in 2012/13) 18–42 for the 1973–78 cohort (baseline in 1996) General women’s health Representative sample of Australian women 21,032
Bogalusa Heart Study 3–80 (when studied) 1st gen 30–70, 2nd gen 12–45 (now) Cardiovascular Black and white, semi-rural men and women 4049 women, 3500 with pregnancy data, 917 generation 2
CARDIA Age 18–30 years at baseline (1985–1986), 48–60 years in 2015–2016 Multi-center USA Cardiovascular 50% Black and 50% White men and women, multiple exams every 2 to 5 years during the 30 years of follow up; 2787 women enrolled; gravidity and parity at exams; (1,392 women who had 2,510 births after baseline during 30-y follow up; 1,951 women gave birth before and/or after baseline)
CoLab Prepregnancy and Early Pregnancy Consortium > 18 y/o (Adults) and associated children General Women’s Health with Pregnancy Focus National and international collaboration to share biosamples and clinical data in the peripregnancy time frame. 13478 to date (enrollment ongoing)
Growing Up Today Study 7–16 (2 enrollment waves 1996 and 2004) now 20–36 Child health Children of women in Nurses’ Health Study II 27, 706 (13,000 in active follow-up)
Hispanic Community Health Study/Study of Latinos 18–74 baseline (2008–2011), 24–80 (2014–2017), 3rd 2020–2023 Cardiovascular Largest Hispanic health study in the US 16,415; 9835 women, 3801 aged 18–41; 440 mom-child dyads (ancillary; 2019–2021)
NHLBI Growth and Health Study 9–28 (when studied) 40–42 (now) Cardiovascular Girls enrolled in 1987 at age 9–10, 50% black 50% white, followed annually or biannually first 20 years 871 enrolled, approx. 500 in follow-up
Nurses’ Health Study 3 18–52 (mothers) General women’s health Nurses in N. America 45,066 enrolled, 6,623 pregnancies (at least 20 wks) to date
Women or couples attempting pregnancy
Canadian Assisted Reproductive Technology Cohort Study (CARTS) Couples (30–45 years) who underwent IVF/ICSI treatment Long-term outcomes in mothers and their offspring child 18000 couples who under infertility treatment in Canadian province of Ontario with success pregnancy; follow-up through provincial health record linkage is possible 18000 mother-baby pairs (up to December 2018)
Chinese Preconception Cohort Study (CPCS) Couples (18–35 years) plan to have baby soon (< 6 months) Long-term outcomes in mothers and their offspring child 5000 couples who planned to have a baby soon in Liuyang, China; follow-up at 8–12 years after childbirth was planned 2000 mother-baby pairs
CoLab Prepregnancy and Early Pregnancy Consortium > 18 y/o General Women’s Health with Fertility/Pregnancy Focus National and international collaboration to share biosamples and clinical data in the peripregnancy time frame. 516 to date (enrollment ongoing)
EAGeR 18–40 (when studied) 24–46 (now) Fertility Women with 1–2 prior pregnancy losses attempting pregnancy 1228
Early Pregnancy Study Median age is 29, range ~ 22–40 Early loss Women from the Triangle area of North Carolina, enrolled in 1982–86, 221
HOPE Study Preconception (women ages 18–35, men ages 18–40 upon enrollment) Environment Heterosexual couples trying to conceive, greater Salt Lake City area, primarily white 183 couples, 170 with follow-up information
LIFE 18–40 (when studied), 27–53 (now) Fertility Couples attempting pregnancy 501
Time to Pregnancy in Couples of Proven Fecundity Women age 18–35 Fertility awareness instruction 143 women attempting to conceive, prior pregnancy, greater Salt Lake City area, primarily white 140
Preconceptional Offspring Trajectory Study (PLOTS) 20s (two years follow up now) Environmental, social determinants and life style etc. on Fertility, pregnancy outcomes, child health Preconception couples followed up to conception and childbirth, continue to follow offspring at least 3000 couples
Pregnancy Study Online (PRESTO) Men ≥21 years; women aged 21–45 years Fertility, pregnancy, child’s health, environment Preconception cohort of North American (50 US states and 10 Canadian provinces) couples attempting pregnancy 11,000 North American women; 2,500 North American men
Retrospective cohort study of assisted reproductive technology Mothers 20–40 (at time of birth), all stillbirths and live births (with follow up to one year of age) Infertility treatment and child health All births between April 1, 2012 and October 31, 2015 in Ontario captured by BORN, the provincial perinatal registry 17,907 assisted pregnancies
Shanghai Birth Cohort ≥ 20 years Pregnancy Women in two preconception care clinics 1180
Snart Gravid (“Soon Pregnant”), Snart Foraeldre (“Soon Parents”) Men ≥21 years; women 21–49 years Fertility, pregnancy, child’s health, environment Preconception cohort of Danish couples attempting pregnancy 13,500 women (mothers); 1,200 Danish men (fathers)
Strong Healthy Women and SMART Strong Healthy Women (adapted for mHealth delivery) 18–35 (when studied) 28–50 (now) General women’s health and pregnancy Preconception women residing in rural and urban communities in Central PA 692* (*includes N=45 women who became pregnant during 12-month follow-up)
Time to Conceive 30–44 at enrollment in 2008–2015 Biomarkers of fertility Women with no history of infertility, over age 30, from the Triangle area of North Carolina 750
University of Iowa Women’s Health Tissue Repository 18–50 General Women’s Health, Fertility, Reproductive Endocrinology, pregnancy and long-term outcomes Individuals and couples seeking care in the Reproductive Endocrinology & Infertility clinic at the University of Iowa 377 to date (enrollment ongoing)
Upstate KIDS 0–3 years (now 8 years ongoing) Child health Population based cohort oversampled on conceptions by infertility treatment in upstate NY 5034 mothers, 6171 children (twins and higher order multiples included)

CARDIA, Coronary Artery Risk Development in Young Adults; EAGeR, Effects of Aspirin in Gestation and Reproduction; HCHS/SOL, Hispanic Community Health Study/Study of Latinos; HOPE, Home Observation of Periconceptional Exposures; LIFE, Longitudinal Investigation of Fertility and the Environment; NCS, National Children’s Study; NGHS, National Growth and Health Study; GUTS, Growing Up and Today Study; PLOTS, Preconceptional Offspring Trajectory Study; PRESTO, Pregnancy Study Online; SMART, KIDS