Table 3.
STUDY | AGE RANGE | STUDY FOCUS | STUDY POPULATION DESCRIPTION | N |
---|---|---|---|---|
Reproductive-aged women | ||||
Australian Longitudinal Study on Women’s Health | 18–27 for the 1989–95 cohort (baseline in 2012/13) 18–42 for the 1973–78 cohort (baseline in 1996) | General women’s health | Representative sample of Australian women | 21,032 |
Bogalusa Heart Study | 3–80 (when studied) 1st gen 30–70, 2nd gen 12–45 (now) | Cardiovascular | Black and white, semi-rural men and women | 4049 women, 3500 with pregnancy data, 917 generation 2 |
CARDIA | Age 18–30 years at baseline (1985–1986), 48–60 years in 2015–2016 Multi-center USA | Cardiovascular | 50% Black and 50% White men and women, multiple exams every 2 to 5 years during the 30 years of follow up; | 2787 women enrolled; gravidity and parity at exams; (1,392 women who had 2,510 births after baseline during 30-y follow up; 1,951 women gave birth before and/or after baseline) |
CoLab Prepregnancy and Early Pregnancy Consortium | > 18 y/o (Adults) and associated children | General Women’s Health with Pregnancy Focus | National and international collaboration to share biosamples and clinical data in the peripregnancy time frame. | 13478 to date (enrollment ongoing) |
Growing Up Today Study | 7–16 (2 enrollment waves 1996 and 2004) now 20–36 | Child health | Children of women in Nurses’ Health Study II | 27, 706 (13,000 in active follow-up) |
Hispanic Community Health Study/Study of Latinos | 18–74 baseline (2008–2011), 24–80 (2014–2017), 3rd 2020–2023 | Cardiovascular | Largest Hispanic health study in the US | 16,415; 9835 women, 3801 aged 18–41; 440 mom-child dyads (ancillary; 2019–2021) |
NHLBI Growth and Health Study | 9–28 (when studied) 40–42 (now) | Cardiovascular | Girls enrolled in 1987 at age 9–10, 50% black 50% white, followed annually or biannually first 20 years | 871 enrolled, approx. 500 in follow-up |
Nurses’ Health Study 3 | 18–52 (mothers) | General women’s health | Nurses in N. America | 45,066 enrolled, 6,623 pregnancies (at least 20 wks) to date |
Women or couples attempting pregnancy | ||||
Canadian Assisted Reproductive Technology Cohort Study (CARTS) | Couples (30–45 years) who underwent IVF/ICSI treatment | Long-term outcomes in mothers and their offspring child | 18000 couples who under infertility treatment in Canadian province of Ontario with success pregnancy; follow-up through provincial health record linkage is possible | 18000 mother-baby pairs (up to December 2018) |
Chinese Preconception Cohort Study (CPCS) | Couples (18–35 years) plan to have baby soon (< 6 months) | Long-term outcomes in mothers and their offspring child | 5000 couples who planned to have a baby soon in Liuyang, China; follow-up at 8–12 years after childbirth was planned | 2000 mother-baby pairs |
CoLab Prepregnancy and Early Pregnancy Consortium | > 18 y/o | General Women’s Health with Fertility/Pregnancy Focus | National and international collaboration to share biosamples and clinical data in the peripregnancy time frame. | 516 to date (enrollment ongoing) |
EAGeR | 18–40 (when studied) 24–46 (now) | Fertility | Women with 1–2 prior pregnancy losses attempting pregnancy | 1228 |
Early Pregnancy Study | Median age is 29, range ~ 22–40 | Early loss | Women from the Triangle area of North Carolina, enrolled in 1982–86, | 221 |
HOPE Study | Preconception (women ages 18–35, men ages 18–40 upon enrollment) | Environment | Heterosexual couples trying to conceive, greater Salt Lake City area, primarily white | 183 couples, 170 with follow-up information |
LIFE | 18–40 (when studied), 27–53 (now) | Fertility | Couples attempting pregnancy | 501 |
Time to Pregnancy in Couples of Proven Fecundity | Women age 18–35 | Fertility awareness instruction | 143 women attempting to conceive, prior pregnancy, greater Salt Lake City area, primarily white | 140 |
Preconceptional Offspring Trajectory Study (PLOTS) | 20s (two years follow up now) | Environmental, social determinants and life style etc. on Fertility, pregnancy outcomes, child health | Preconception couples followed up to conception and childbirth, continue to follow offspring | at least 3000 couples |
Pregnancy Study Online (PRESTO) | Men ≥21 years; women aged 21–45 years | Fertility, pregnancy, child’s health, environment | Preconception cohort of North American (50 US states and 10 Canadian provinces) couples attempting pregnancy | 11,000 North American women; 2,500 North American men |
Retrospective cohort study of assisted reproductive technology | Mothers 20–40 (at time of birth), all stillbirths and live births (with follow up to one year of age) | Infertility treatment and child health | All births between April 1, 2012 and October 31, 2015 in Ontario captured by BORN, the provincial perinatal registry | 17,907 assisted pregnancies |
Shanghai Birth Cohort | ≥ 20 years | Pregnancy | Women in two preconception care clinics | 1180 |
Snart Gravid (“Soon Pregnant”), Snart Foraeldre (“Soon Parents”) | Men ≥21 years; women 21–49 years | Fertility, pregnancy, child’s health, environment | Preconception cohort of Danish couples attempting pregnancy | 13,500 women (mothers); 1,200 Danish men (fathers) |
Strong Healthy Women and SMART Strong Healthy Women (adapted for mHealth delivery) | 18–35 (when studied) 28–50 (now) | General women’s health and pregnancy | Preconception women residing in rural and urban communities in Central PA | 692* (*includes N=45 women who became pregnant during 12-month follow-up) |
Time to Conceive | 30–44 at enrollment in 2008–2015 | Biomarkers of fertility | Women with no history of infertility, over age 30, from the Triangle area of North Carolina | 750 |
University of Iowa Women’s Health Tissue Repository | 18–50 | General Women’s Health, Fertility, Reproductive Endocrinology, pregnancy and long-term outcomes | Individuals and couples seeking care in the Reproductive Endocrinology & Infertility clinic at the University of Iowa | 377 to date (enrollment ongoing) |
Upstate KIDS | 0–3 years (now 8 years ongoing) | Child health | Population based cohort oversampled on conceptions by infertility treatment in upstate NY | 5034 mothers, 6171 children (twins and higher order multiples included) |
CARDIA, Coronary Artery Risk Development in Young Adults; EAGeR, Effects of Aspirin in Gestation and Reproduction; HCHS/SOL, Hispanic Community Health Study/Study of Latinos; HOPE, Home Observation of Periconceptional Exposures; LIFE, Longitudinal Investigation of Fertility and the Environment; NCS, National Children’s Study; NGHS, National Growth and Health Study; GUTS, Growing Up and Today Study; PLOTS, Preconceptional Offspring Trajectory Study; PRESTO, Pregnancy Study Online; SMART, KIDS