Table 2.
Summary of GI50 Values Calculated from MTT Assay (72 Hrs) in Gastric Cell Lines for All Test Agents. GI50 Is Mean ± SD from Three Independent Trials, Where N = 4
| Test Agent | GI50 ± SD (µM) | ||||
|---|---|---|---|---|---|
| Cell Line | |||||
| MKN-45 | NCI-N87 | KATO-III | BGC-823 | SGC-7901 | |
| 5F 203 | 0.079±0.026 | 0.38 | 33.3±20.9 | >51 | 14.1±18.5 |
| AFt/5F 203 | 0.011±0.004 | 0.029±0.013 | 0.26±0.2 | >0.7 | >0.7 |
| GW610 | 0.43±0.37 | 0.41±0.34 | 7.7±1.1 | 18.6±14.1 | 35.1±8.6 |
| AFt-GW610 | 0.036±0.032 | 0.48±0.34 | 0.42±0.33 | 1.4±0.5 | >1.8 |
| GW608Lys | 22.1±16.8 | 38.1 | 41.7±21.4 | >50 | 25.9±22.5 |
| AFt/GW608Lys | 0.21±0.13 | 0.59 | >3.5 | >3.5 | >3.5 |