Table 1.
Demographic, Anthropometric, Physiological and Clinical Characteristics of Patients. Mean (SD) or n (%)
| All Patients (n=200) | COPD (n=96) | HYPOX (n=63) | LTOT (n=41) | P | |
|---|---|---|---|---|---|
| Male, % | 77.0 | 78.1 | 74.6 | 78.0 | 0.861 |
| Age, years | 68.7 (9.1) | 69.9 (8.6) | 67.9 (11.0) | 67.0 (6.4) | 0.153 |
| BMI, kg/m2 | 26.3 (5.4) | 26.6 (5.0) | 26.3 (6.0) | 25.6 (5.4) | 0.655 |
| 6MWD, m | 432.0 (111.5) | 457.8 (97.9) | 442.3 (113.5) | 354.0 (106.2) | <0.001 (&=<0.001, #=<0.001) |
| Mean SpO2 6MWD, % | 90.54 (3.82) | 93.50 (2.07) | 88.47 (2.60) | 86.76 (3.15) | <0.001 (*=<0.001, &=<0.001, #=0.003) |
| FEV1, % pred. | 61.5 (23.6) | 72.3 (21.1) | 57.5 (21.5) | 42.9 (18.3) | <0.001 (*=<0.001, &=<0.001, #=0.002) |
| FVC, % pred. | 87.1 (21.7) | 95.0 (20.6) | 83.1 (20.4) | 75.5 (19.4) | <0.001 (*=0.003, &=<0.001) |
| FEV1/FVC,% | 53.3 (16.8) | 57.6 (12.4) | 52.7 (20.7) | 44.0 (15.3) | <0.001 (&=<0.001, #=0.033) |
| RV, % pred. | 143.7 (49.1) | 133.3 (36.0) | 149.3 (49.1) | 159.9 (68.0) | 0.027 (&=0.034) |
| CI, score | 1.6 (0.3) | 1.6 (0.3) | 1.6 (0.3) | 1.8 (0.3) | <0.001 (&=0.002, #=0.001) |
| SI, score | 2.8 (1.6) | 2.8 (1.5) | 2.5 (1.7) | 3.4 (1.4) | 0.023 (#=0.020) |
| PaO2/FiO2 | 340 (54) | 366 (44) | 337 (47) | 284 (42) | <0.001 (*=<0.001, &=<0.001, #=<0.001) |
| PaCO2, mmHg | 37.94 (4.78) | 36.9 (4.1) | 37.6 (4.2) | 40.7 (5.8) | <0.001 (&=<0.001, #=0.003) |
| MVC quadriceps, kg | 30.4 (10.6) | 29.8 (10.2) | 31.8 (11.6) | 29.4 (10.3) | 0.422 |
| MVC biceps, kg | 22.0 (7.4) | 22.8 (7.7) | 22.4 (7.3) | 19.8 (6.2) | 0.079 |
| MIP, cmH2O | 75.0 (23.3) | 72.4 (25.0) | 76.2 (19.8) | 79.0 (24.0) | 0.286 |
| MEP, cmH2O | 101.3 (34.6) | 102.1 (35.7) | 101.9 (32.9) | 98.4 (33.6) | 0.839 |
| EQ-5D, score | 0.68 (0.34) | 0.72 (0.31) | 0.71 (0.30) | 0.54 (0.47) | 0.035 (&=0.037) |
| EQ-5D-VAS | 64.0 (19.7) | 66.3 (19.5) | 62.2 (21.7) | 61.0 (15.0) | 0.333 |
Notes: P=ANOVA test. In brackets P of post hoc analysis with Bonferroni correction: #= LTOT vs HYPOX; & = LTOT vs COPD; * = COPD vs HYPOX.
Abbreviations: 6MWD, 6-min walk distance; BMI, body mass index; CI, Comorbidity Index; COPD, chronic obstructive pulmonary disease; EQ-5D, EuroQol five dimension questionnaire; EQ-5D-VAS, EuroQol five dimension – VAS; FEV1, forced expiratory flow in one second; FVC, forced vital capacity; MEP, maximal expiratory pressure; MIP, maximal inspiratory pressure; MVC, maximal voluntary contraction; PaCO2, arterial carbon dioxide tension; PaO2, arterial oxygen tension; SI, Severity Index.