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. 2019 Dec 5;14:9577–9586. doi: 10.2147/IJN.S218748

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© 2019 Chen et al.

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IL-6 upregulation caused by InP/ZnS QD exposure can be alleviated by ROS scavengers in macrophages. (A, B) After treatment with InP/ZnS QDs for 24 h, the BMMs were stained with DCFH-DA or MitoSOX. The intracellular ROS and the mtROS were measured with flow cytometry (A). The levels of intracellular ROS and mtROS are presented as bar graphs (B). (C) After scavenging ROS with NAC (10 mM), DPI (12.5 mM), or mito-TEMPO (50 μM) for 15 min, the BMMs were treated with InP/ZnS QDs for 24 h. IL-6 release was measured with ELISA. The results are representative of three independent experiments. *P < 0.05 and **P < 0.01, compared to the controls.

Abbreviations: IL-6, interleukin-6; QDs, quantum dots; ROS, reactive oxygen species; BMMs, bone marrow-derived macrophages; DCFH-DA, 2ʹ,7ʹ-dichlorodihydrofluorescein diacetate; mtROS, mitochondrial ROS; NAC, N-acetylcysteine; DPI, diphenylene iodonium; ELISA, enzyme-linked immunosorbent assay; ND, not detected.