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. 2019 Dec 5;12:239–248. doi: 10.2147/TACG.S186476

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© 2019 Pisani.

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(A) A homology model for the human DDX11 helicase based on an archaeal XPD X-ray structure (PDB ID: 4A15). (B) Schematic representation of the human DDX11 polypeptide chain showing location of the amino-acid substitutions described in WABS-affected individuals (see text for details). The domain color-coded is as follows: RecA homology domain 1, HD1, green, and 2, HD2, dark blue; conserved helicase motifs, light blue; Fe-S cluster domain, orange; Arch domain, pink; partially unstructured insertion between motifs I and Ia, red.