Table 2.

Utility Values For The Health States And Disutility Values Associated With Adverse Events And Route Of Administration

Variables	Base Case	Range	Distribution	Source
Disease progression
Progression-free	0.804	0.536–0.840	Beta	29,40
Progressive disease	0.470	0.190–0.560	Beta	29,40
Utility decrement of SAEs
Diarrhoea	−0.119	0.108–0.132	Beta	29,41
Rash or acne	−0.099	0.032–0.151	Beta	29,41
Stomatitis or mucositis	−0.102	0.091–0.112	Beta	29,41
Vomiting	−0.125	0.048–0.288	Beta	29,41
Anaemia	−0.191	0.172–0.211	Beta	29,41
Neutropenia	−0.189	0.171–0.209	Beta	29,41
Thrombocytopenia	−0.108	0.097–0.119	Beta	29,41
Route of administration
Intravenous therapy	−0.043	0.004–0.082	Beta	16
Oral therapy	0.014	0.000–0.037	Beta	16

Abbreviation: SAEs, serious adverse events.