Table 2.
Sensitivity and Specificity of decision criteria. These are the results of applying both our decision tree model and the manufacturer recommended cutoffs to those subjects with known disease status.
| Zika PCR+ | Dengue PCR+ | Household | ||||
|---|---|---|---|---|---|---|
| Sensitivity | Specificity | Sensitivity | Specificity | Sensitivity | Specificity | |
| Performance of Tree Model1 | 13/32 = 41% |
137/140 = 98% |
50/59 = 85% |
103/113 = 91% |
75/81 = 93% |
70/91 = 77% |
|
Manufacturer Cutoffs: IgM Day 0 |
0/32 = 0% |
140/140 = 100% |
36/59 = 61% |
104/113 = 92% |
75/81 = 93% |
39/91 = 43% |
|
Manufacturer Cutoffs: IgM Day 28 |
1/32 = 3% |
139/140 = 99% |
33/59 = 56% |
99/113 = 88% |
72/81 = 89% |
39/91 = 43% |
|
Manufacturer Cutoffs: IgG Day 0 |
30/32 = 94% |
20/140 = 14% |
33/59 = 56% |
80/113 = 71% |
7/81 = 9% |
69/91 = 76% |
|
Manufacturer Cutoffs: IgG Day 28 |
30/32 = 94% |
16/100 = 16% |
46/59 = 78% |
73/113 = 65% |
8/81 = 10% |
81/91 = 89% |
1
Calculated on out-of-fold predictions with 10-fold cross-validation