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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neurobiol Aging. 2019 Feb 20;78:142–154. doi: 10.1016/j.neurobiolaging.2019.02.012

Figure 2.

Figure 2

The KEGG pathway “oxidative phosphorylation” (3.17-fold enriched, p = 5.5 × 10−7) overlaid with microarray data - blue highlight identifies genes showing significantly increased expression in association with physical activity and decreased expression in Aging or AD. Significant genes included approximately 30% of the genes encoding mitochondrial complex I (NADH:ubiquinone oxidoreductase) (NDUFA1, NDUFA7, NDUFA8, NDUFA9, NDUFAF5, NDUFB1,NDUFB8, NDUFB9, NDUFS1, NDUFS3, NDUFS5, NDUFV2 and NDUFV3) approximately 35% of the genes encoding Complex IV (cytochrome C oxidase)(subunits COX4l1, COX6A1, COX6C, COX7B, COX7A2, COX8A and COX11) and Complex V (ATP synthase)(ATP5A1, ATP5C1, ATP5O, ATP5G1, ATP5L, ATP51), as well as 2 components (SLC25A27, SLC25A14) of the uncoupling protein. No genes in the pathway showed decreased expression in association with physical activity.