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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Neurobiol Aging. 2019 Feb 20;78:142–154. doi: 10.1016/j.neurobiolaging.2019.02.012

Figure 3.

Figure 3

The synaptic vesicle KEGG pathway overlaid with microarray analysis with blue highlight identifying genes showing significantly increased expression in association with physical activity and decreased expression in Aging or AD. Significant genes are involved in synaptic vesicle trafficking, priming and docking at the active zone: SNAP25, synaptobrevin/VAMP2, synapsin 2 (SYN2), syntaxin binding protein 1 (STXBP1)) as well as synaptic vesicle endocytosis and recycling (dynamin-like 1 (DNML1), DNML3, adaptor protein complex 2 (AP2M1). No genes in the pathway showed decreased expression in association with physical activity.