Table 1.

DAVID enrichment categories for unambiguous probesets with hippocampal expression significantly increased in association with physical activity and significantly decreased with Aging or AD. Note that significant genes may be contained with in multiple enriched terms within a category.

Mitochondria-related categories	Database	Term	Count	%	EASE PValue	List Total	Pop Hits	Pop Total	Fold Enrichment	Benjamini
Mitochondrion	UP_KEYWORDS		143	12.16	1.98E-07	1138	881	10612	1.51	2.04E-05
Mitochondrion	GOTERM_CC_DIRECT	GO:0005739	162	13.78	3.57E-08	1047	1026	9961	1.50	7.04E-06
Mitochondrion inner membrane	UP_KEYWORDS		55	4.68	2.12E-09	1138	218	10612	2.35	4.39E-07
Mitochondrion inner membrane	GOTERM_CC_DIRECT	GO:0005743	74	6.29	2.77E-08	1047	364	9961	1.93	8.20E-06
Mitochondrion outer membrane	UP_KEYWORDS		19	1.62	3.41E-03	1138	85	10612	2.08	9.60E-02
Respiratory chain	UP_KEYWORDS		17	1.45	1.41E-04	1138	55	10612	2.88	8.26E-03
oxidative phosphorylation	KEGG_PATHWAY	hsa00190	33	2.81	2.19E-09	380	107	3909	3.17	5.54E-07
mitochondrial respiratory chain complex I	GOTERM_CC_DIRECT	GO:0005747	15	1.28	5.70E-05	1047	42	9961	3.40	4.81E-03
ubiquinone	UP_KEYWORDS		10	0.85	1.88E-03	1138	28	10612	3.33	6.83E-02
mitochondrial electron transport, NADH to ubiquinone	GOTERM_BP_DIRECT	GO:0006120	15	1.28	6.51E-05	972	43	9380	3.37	9.24E-02
mitochondrial proton-transporting ATP synthase complex	GOTERM_CC_DIRECT	GO:0005753	8	0.68	2.23E-03	1047	19	9961	4.01	9.67E-02
Metabolic pathways	KEGG_PATHWAY	hsa01100	103	8.76	6.18E-04	380	792	3909	1.34	2.21E-02

Synapse, plasticity -related categories	Database	Term	Count	%	EASE PValue	List Total	Pop Hits	Pop Total	Fold Enrichment	Benjamini
Synapse	UP_KEYWORDS		60	5.10	1.23E-09	1138	245	10612	2.28	5.06E-07
synaptic vesicle membrane	GOTERM_CC_DIRECT	GO:0030672	16	1.36	4.16E-06	1047	39	9961	3.90	4.92E-04
chemical synaptic transmission	GOTERM_BP_DIRECT	GO:0007268	31	2.64	3.31E-05	972	134	9380	2.23	9.38E-02
Postsynaptic cell membrane	UP_KEYWORDS		26	2.21	1.46E-04	1138	108	10612	2.24	7.50E-03
Postsynaptic membrane	GOTERM_CC_DIRECT	GO:0045211	29	2.47	2.08E-04	1047	132	9961	2.09	1.36E-02
crebPathway:Transcription factor CREB and its extracellular signals	BIOCARTA		9	0.77	1.89E-03	102	26	1060	3.60	6.89E-02
axon	GOTERM_CC_DIRECT	GO:0030424	38	3.23	3.40E-05	1047	178	9961	2.03	3.35E-03
myelin sheath	GOTERM_CC_DIRECT	GO:0043209	36	3.06	7.04E-07	1047	140	9961	2.45	1.04E-04
growth cone	GOTERM_CC_DIRECT	GO:0030426	23	1.96	1.62E-04	1047	92	9961	2.38	1.19E-02
neuron projection	GOTERM_CC_DIRECT	GO:0043005	31	2.64	1.87E-03	1047	165	9961	1.79	9.56E-02
Cell junction	UP_KEYWORDS		78	6.63	4.37E-06	1138	433	10612	1.68	3.61E-04
Cell junction	GOTERM_CC_DIRECT		66	5.61	2.16E-08	1047	308	9961	2.04	1.28E-05

Other categories	Database	Term	Count	%	EASE PValue	List Total	Pop Hits	Pop Total	Fold Enrichment	Benjamini
gap junction	KEGG_PATHWAY	hsa04540	16	1.36	1.25E-03	380	66	3909	2.49	3.12E-02
Circadian entrainment	KEGG_PATHWAY	hsa04713	17	1.45	6.86E-04	380	69	3909	2.53	2.15E-02
Transport	UP_KEYWORDS		172	14.63	4.71E-04	1138	1265	10612	1.27	2.14E-02
Transit peptide	UP_KEYWORDS		77	6.55	1.07E-05	1138	436	10612	1.65	7.33E-04
chrebpPathway:ChREBP regulation by carbohydrates and cAMP	BIOCARTA		9	0.77	3.51E-05	102	16	1060	5.85	6.62E-03
agpcrPathway:Attenuation of GPCR Signaling	BIOCARTA		7	0.60	2.02E-04	102	11	1060	6.61	1.89E-02
cskPathway:Activation of Csk by cAMP-dependent Protein Kinase Inhibits Signaling through the T Cell Receptor	BIOCARTA		7	0.60	1.03E-03	102	14	1060	5.20	6.30E-02
plcePathway:Phospholipase C-epsilon pathway	BIOCARTA		6	0.51	1.22E-03	102	10	1060	6.24	5.60E-02
raccPathway:Ion Channels and Their Functional Role in Vascular Endothelium	BIOCARTA		6	0.51	2.07E-03	102	11	1060	5.67	6.31E-02
nos1Pathway:Nitric Oxide Signaling Pathway	BIOCARTA		7	0.60	2.35E-03	102	16	1060	4.55	6.15E-02
gpcrPathway:Signaling Pathway from G-Protein Families	BIOCARTA		9	0.77	3.19E-03	102	28	1060	3.34	7.28E-02