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. Author manuscript; available in PMC: 2020 Dec 1.
Published in final edited form as: Bioorg Med Chem Lett. 2019 Oct 14;29(23):126713. doi: 10.1016/j.bmcl.2019.126713

Scheme 2.

Scheme 2.

Representative examples for the synthesis of analogs from intermediate I. Reagents and conditions: (i) 2 M sodium carbonate in water, palladium(0)tetrakis(triphenylphosphine), dimethoxyethane, 90 °C, analogous procedures for 8b–8e; (ii) sodium hydride (60% in mineral oil), NMP, 21–25 °C then 50 °C, analogous procedure for 9b; (iii) DMF, 90 °C, analogous procedure for 10b.