Table 3.

Secondary Clinical Endpoints

Secondary Clinical Endpoints
• Percentage of volunteers with diarrhea	• Maximum 24-h stool output
• Mean/median time to onset of diarrhea	• Total loose stool output
• Mean/median duration of diarrhea	• Percentage of volunteers with nausea, vomiting, anorexia, gas, or abdominal pain/cramps rated as moderate to severe
• Shigella disease severity score postchallenge	• Percentage of subjects with dysentery
• Percentage of subjects with fever	• Percentage of subjects requiring intravenous fluids
• Percentage of subjects requiring early antibiotic therapy