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. 2019 Nov 25;17(11):e3000434. doi: 10.1371/journal.pbio.3000434

Fig 9. Solid tumor-expressed GPCRs with potential as drug targets.

Fig 9

(A) The number of GPCRs that are targets for approved drugs and have increased expression in 1–3, 4–9, or ≥10 tumor subtypes. (B) The linkage to G proteins of the 77 GPCRs targeted by approved drugs and with increased expression in at least 1 tumor subtype. Note: multiple GPCRs couple to more than one G protein. (C) The number of GPCRs targeted by approved drugs that show increased expression in lung, colon, pancreatic, breast, and prostate cancers, the leading causes of cancer deaths in the US. (D) Overrepresentation of GPCRs among genes with >4-fold elevated expression (FDR < 0.05) for the indicated tumor types/subtypes with p-value calculated via Fischer’s exact test. (E) The magnitude of overrepresentation (relative enrichment) of GPCRs corresponding to the p-value in panel H. Numerical values used to generate panel C can be found in S2 Table, in sheets on DE of druggable GPCRs. Numerical values for panels D and E can be found at https://insellab.github.io/data. ACC, Adrenocortical Cancer; Ad, Adenocarcinoma; BRCA, breast cancer; CESC, Cervical Cancer; COAD, colon adenocarcinoma; DE, differential expression; ESCA, esophageal cancer; FDR, false discovery rate; GPCR, G protein-coupled receptor; Her2, Human Epidermal Growth Factor Receptor-2; IDC, infiltrating ductal carcinoma; KIRC, kidney clear cell carcinoma; KIRP, kidney papillary cell carcinoma; LIHC, liver hepatocellular carcinoma; LSQC, lung squamous cell carcinoma; LUAD, lung adenocarcinoma; NOS, Not Otherwise Specified; OV, ovarian cancer; PDAC, pancreatic ductal carcinoma; PRAD,; SKCM, skin cutaneous melanoma; STAD, stomach adenocarcinoma; TGCT, testicular cancer; THCA, thyroid cancer; UCS, Uterine Carcinosarcoma.